Zones of red coloration are produced by a rich capillary bed perfused with haemoglobin-carrying red blood cells, while the zones of blue are structural colours produced by coherent scattering of light from oriented arrays of dermal collagen [ 9 ]. In some female catarrhines, the perineal skin turns pink or red near the time of ovulation as blood and interstitial fluid infuses the region as an advertisement of oestrus [ 1011 ]; in some macaques, these changes are also accompanied by darkening of the facial skin, presumably also caused by perfusion of the region by blood [ 12 ].
In Old World monkeys and apes, the intensity of coloration of glabrous skin is under hormonal control and is considered a sign of fertility in females and competitive ability in males [ 12 — 14 ]. The genetic and developmental processes that produce the complex topographical arrangements of coloration on the face, trunk and limbs are not well understood [ 15 ], and are still mostly a matter of conjecture.
The fact that many patterns follow presumed pathways of migration of the neural crest-derived melanocytes into the face and trunk during development warrants further study [ 5 ]. Humans are distinguished from their non-human relatives by an absence of most fur and an almost complete lack of regional patterning in hair coloration, except for male facial hair in some populations [ 16 ].
The remnants of the primate hair coat are the localized concentrations of non-agouti terminal hairs of similar colour that occur on the scalp, and of a different type in the axillae and pubic region. The evolution of hair loss in the human lineage has been discussed extensively in the literature and is reviewed elsewhere [ 17 ].
Because skin is mostly not preserved in the fossil record, arguments about the evolutionary causation of hair loss have relied on critical examination and integration of pertinent comparative anatomical, physiological, palaeoecological and climatological evidence. This evidence is consistent with an explanation based on natural selection for enhanced thermoregulation during high physical activity levels under conditions of high environmental heat load [ 18 — 20 ].
Under these conditions, most body hair was lost and a high density and broad somatic coverage of eccrine sweat glands was gained in order to increase the capacity for heat dissipation by evaporation from the surface of the skin [ 21 — 23 ]. Loss of body hair was accompanied by disadvantages, notably, loss of some protection against abrasion and ultraviolet radiation UVR. Compensatory changes evolved quickly in hominin skin, as evidenced by genomic comparisons between humans and our closest relative, the chimpanzee.
These have revealed that the human lineage is characterized by accelerated evolution of keratinization and epidermal differentiation genes that contribute to enhanced barrier functions of the epidermis [ 24 — 26 ]. While these changes were occurring, others affecting constitutive pigmentation soins du visage gradignan ouverture also taking place.
Decades before genomic evidence became available, the timing of the origin of permanent darkly pigmented skin over the entire hominin body surface had been deduced from anatomical, physiological and climatological evidence [ 27 ]. Since genomic evidence has become available, comparative study of the human melanocortin 1 receptor MC1R locus demonstrated that the timing of evolution of permanent, dark, eumelanin-rich, skin pigmentation coincided with the evolution of functional hairlessness and increased density of eccrine sweat glands early in the history of the genus Homoapproximately 1.
Adaptive evolution for sun-resistant alleles of the MC1R locus appears to have occurred, therefore, when early members of the genus Homo became mostly hairless and highly physically active inhabitants of open savannah environments in Africa. For members of the Homo lineage evolving since then in sub-Saharan Africa—including the earliest modern people, Homo sapiens —the absence of functional polymorphism has been maintained by purifying selection [ 2930 ].
Protective, eumelanin-rich constitutive pigmentation has persisted because of its contribution towards the survival and successful reproduction of populations living under high UVR at low latitudes.
Skin colour as measured by skin reflectance and levels of UVR are highly correlated. Biologically effective UVR is often described in units of minimal erythemal dose or MED, which expresses the amount of UVR radiation that will produce minimal erythema sunburn or redness caused by engorgement of capillaries in lightly pigmented human skin within a few hours following UVR exposure.
If this relationship developed under natural selection, plausible causation must demonstrate real or probable enhanced reproductive success for specific skin pigmentation phenotypes under specific UVR conditions. Many adaptive explanations for the evolution of variation in human skin colour have been put forward in the last century, as reviewed elsewhere [ 17 ], and most have suffered from a lack of evidence for likely differences in survivorship and reproduction of different skin colour phenotypes under the same UVR conditions.
Skin cancers rarely cause death or adversely affect reproductive success during the peak reproductive years [ 33 ], so this explanation was dismissed long ago as being a primary cause of the evolution of dark skin pigmentation.
The recent argument that ancestral hominins had pale, cancer-prone skin similar to that of individuals with OCA2 albinism and that evolution of dark skin spared the human lineage from skin cancer—related mortality lacks support [ 34 ]. Other explanations have insufficient explanatory power.
These include the hypothesis that the eumelanin was most important in affording protection against tropical parasites and tropical skin diseases because of its potent antimicrobial properties [ 35 — 37 ], an idea that fails to explain the near-absence of eumelanin on the primary environmental interfaces of the volar surfaces of the hands and feet and the lips.
More recently, mooted is the hypothesis that the primary function of eumelanin was augmentation of epidermal barrier function by increasing the skin's resistance to desiccation under arid conditions, and that depigmentation did not occur under positive selection for vitamin D production [ 38 — 40 ].
This hypothesis has been disproved by multiple lines of evidence, including the fact that tanning occurs in the presence of UVR, not desiccation [ 41 ], and that positive selection for depigmented skin capable of producing vitamin D under low and highly seasonal UVB conditions is now well established [ 42 ].
The strongest hypothesis for the evolution of dark skin colour is that it afforded protection against photodegradation of cutaneous and systemic folate under high UVR conditions for early members of the genus Homo. The physiological effects of photodegradation of folate were explored long before the full extent of folate's roles in DNA biosynthesis, repair, DNA methylation, amino acid metabolism and melanin production were appreciated [ 43 ]. Because folate in its main form of 5-methyltetrahydrofolate or 5-MTHF is sensitive to photodegradation [ 44 — 47 ], protective eumelanin-rich pigmentation evolved in early Homo primarily to prevent reduction of fertility due to loss of folate in cutaneous blood vessels and the systemic circulation [ 2148 ].
Powermatte Lip Pigment
Folate deficiencies are associated with potentially fatal birth defects such as neural tube defects and male infertility [ 49 — 52 ]. Folate metabolism is regulated by genes and epigenomic factors, which have evolved to favour conservation of folate under conditions of longer day length and greater potential UVR-related folate loss [ 5354 ].
Recent physiological evidence also indicates the importance of folate in the form of 5-MTHF in thermoregulation, via its effect on controlling nitric oxide-mediated cutaneous vasodilation [ 55 — 58 ].
Maintaining the integrity of folate metabolism is important with respect to evolution because it directly affects reproductive success and survival early in life [ 2159 ]. Natural selection has, thus, affected varied genetic and physiological mechanisms in order to protect folate and 5-MTHF in the face of high UVR. The primary role of constitutive dark skin colour in hominin and modern human evolution is that of a natural sunscreen to conserve folate. Protection of epidermal DNA against strand breaks was the important secondary role played by dark skin colour.
The genus Homo and the species Homo sapiens emerged in equatorial Africa under conditions of intense and relatively invariant sunlight and UVR. Dispersal of hominins into non-equatorial Africa, Eurasia and the Americas involved movements into habitats with more seasonally variable patterns and differing wavelength mixtures of UVR [ 60 ]. In this review, we shall confine our discussion to the consequences for skin colour of dispersal of Homo sapiens into Eurasia and the Americas, a process which began around 55 years ago [ 61 ].
Dispersing populations were small and bottlenecks further reduced available genetic variation in populations crossing major geographic boundaries [ 62 ]. Note also that there is no evidence that dispersing archaic Homo sapiens used sewn clothing or other methods of full-coverage protection against the sun and elements. Non-sewn animal skins probably afforded some protection, but for the most part people were subjected to the full force of UVR apart from the times when they sought natural shelter.
Skin was thus the primary interface with the environment for most of human evolution. The UVR regimes faced by dispersing hominins were a major selective pressure affecting the evolution of skin pigmentation. Outside of the tropics, consideration of the pattern of UVB is relevant because only some wavelengths of UVB between and nm, with peak synthesis between and nm catalyse production of vitamin D in the skin.
Within the tropics, average UVB is high and has two equinoctial peaks, but outside of the tropics, average UVB levels are lower and exhibit but a single peak at the Summer Solstice [ 60 ].
Because eumelanin in skin is a highly effective sunscreen, the potential for cutaneous vitamin D production is reduced by dark skin [ 2163 — 66 ]. Darkly pigmented hominins dispersing out of equatorial Africa thus faced conditions that significantly affected their vitamin D physiology.
Pre-vitamin D production occurs in skin of all colours, but in eumelanin-rich skin, low doses of UVB do not raise 25 OH D levels to physiologically adequate levels at which storage can take place; higher doses over longer periods of time are required for this, and these conditions are not met outside of equatorial latitudes.
Long-term occupation of non-tropical latitudes, thus, would not have been possible without loss of some constitutive eumelanin pigmentation in order to prevent the serious sequelae of vitamin D deficiency [ 21 ]. At extreme high latitudes, year-round occupation is not possible without a diet that is centred on consumption and storage of vitamin-D rich foods such as oily fish, marine mammals, or caribou and reindeer, which concentrate vitamin D in their muscle meat and fat [ 2170 ].
Melanin produced by the tanning response is the outcome of UV-induced stress and is regulated by melanocortins in the skin [ 71 ]. Melanocortins in the skin reduce the production of reactive oxygen species, enhance repair of DNA damage caused by UVR and inaugurate eumelanin synthesis in individuals who carry specific, naturally expressed variants of MC1R [ 71 ]. Tanning is thus a response to damage caused by UVR.
Contrary to popular belief, tanned skin affords little or no protection from damage from subsequent UVR exposure. Recent experimental studies have shown that a tan developed under suberythemal UVB exposure provides minimal photoprotection, but a tan developed under UVA-rich sunlamps such as those used in tanning salons provided no photoprotective benefit [ 72 — 74 ].
Depigmented skin evolved not once, but multiple times in human history, and was accomplished by different combinations of genetic mutations. For modern European populations, different signatures of selection on the MC1R and SLC24A5 genes imply that both natural selection and genetic drift contributed to the evolution of depigmented skin.
These genetic changes affected the amounts of melanin being produced in melanocytes and the size of the melanosomes in which the melanin was packaged [ 75 ]. For modern eastern Asian populations, depigmentation was not achieved through mutations at the SLC24A5 locus [ 75 ], but via a different set of genetic changes, which are still incompletely known [ 7677 ].
The fact that depigmented skin evolved independently in the ancestors of modern Europeans and East Asians suggests that at least two and probably more distinct genetic mutation events occurred and that multiple loci underwent positive selection in these two regions receiving relatively low levels of UVB [ 78 — 80 ]. The most likely reason for this was that it was associated with a loss of skin pigment that favoured vitamin D production under conditions of low UVB [ 697881 ].
Depigmented skin also evolved independently in Homo neanderthalensis [ 82 ] probably for the same reason. There has been a cause and effect relationship between UVR and skin pigmentation in human evolution, and skin colour phenotypes have been modified under the action of natural selection to maintain an optimum balance between photoprotection and photosynthesis over spatially varying conditions of UVR.
Skin colour thus evolved as the product of two opposing clines, one emphasizing dark pigmentation and photoprotection against high loads of UVA and UVB near the equator, the other favouring depigmented skin to promote seasonal, UVB-induced photosynthesis of vitamin D 3 nearer the poles [ 60 ]. Intermediate latitudes with seasonally high loads of UVB favoured the evolution of people with intermediate colour capable of tanning [ 8485 ].
The most important points to reinforce here are that the geographical gradient of human skin colour evolved under the influence of natural selection, and that very similar skin colour phenotypes dark, light and intermediate have evolved independently numerous times under similar UVR conditions.
Diverse combinations of skin colour genes occurred during the course of prehistory as the programme perte de poids 10 kilos result of natural selection, gene flow due to migration, and founder effect or genetic drift due to population bottlenecks occurring in the course of dispersal events [ 6286 quelle boisson pour eliminer la cellulite. Indigenous populations of the New World have generally lighter skin colours than those of the Old World, probably because they have not resided in their homelands for as long a time and because their adaptations to the environment have been more strongly cultural than biological, as exemplified by the wearing of sewn clothing and the making of shelters [ 212287 ].
Sexual selection does not appear to have been a major influence on the evolution of human skin coloration, but it probably did increase the degree of sexual dimorphism in skin colour in some populations [ 2187 ]. The unexposed skin of females is lighter than that of males in most populations [ 2183 ], possibly because of the greater need of females to produce vitamin D in the skin to absorb and mobilize calcium during pregnancy and lactation. A persistent, directional preference for lighter-coloured females as marriage partners has been recognized during historic times in some east- and south-Asian cultures, and it is likely that this has contributed to the greater sexual dimorphism in coloration observed [ 2187 ].
Like skin, the coloration of human hair and eyes is determined primarily by the amount and type of melanin produced and stored in melanosomes [ 8889 ]. Iris pigmentation is also influenced by structural features within the eye itself and by the degree of pupillary dilation [ 90 — 92 ]. Although skin coloration varies according to the intensity and seasonality of UVR on a global scale, no such regular geographical pattern is observed with hair and eye coloration [ 93 ].
In fact, little variation in hair and eye coloration occurs in indigenous populations outside of Europe for hair and outside of Europe, North Africa, the Middle East, Central Asia and South Asia for eyes [ 888994 ]. The lack of variation in hair and eye coloration in Africa has been assumed to be caused by the importance of eumelanin in affording protection, as it does in the case of skin coloration, but this has not been empirically established.
Hair and eye coloration appear to have not been under as strong natural selection as skin coloration, and loss of genetic variation at one or more population bottlenecks probably contributed to the patterns of phenotypic variation observed in the hair and irises of modern people [ 95 ].
Scalp hair in most non-European populations is very dark brown, with little phenotypic variation [ 96 ]. Many genes appear to contribute to the dark brown hair colour phenotype [ 8893 ], and the relative importance of different loci is not yet known. The relatively high prevalence of blond hair in Northern Island Melanesia has been traced to the 93C allele of the TYRP1 gene [ 9798 ], which has been dispersed throughout the region in the course of human colonization of the Southwest Pacific.
In Europe, blond hair has been traced to establishment of variation in a regulatory enhancer of the KITLG gene, while red hair is produced by a specific range of variants of the MC1R locus [ 99 — ]. Sexual selection is thought to have influenced the high prevalence of blond- and red-hair phenotypes in Europe [ 93 ], but this has not been established empirically.
The nature and coloration of human male facial hair—beards and moustaches—have been a matter of curiosity and speculation, but little formal research [ 16, ]. Male facial hair, manifested as moustaches, cheek hair whiskers and beards, occurs in some male primates and appears to represent secondary sexual characteristics that evolved as amplified visual signals of rank, dominance and attractiveness [ 8].
This supports claims that age-related changes in human beard and moustache coverage and colour on the male face serve as honest signals of age or social dominance [ ], and that they evolved as products of contest competition between males [ ].
Beards augment the effectiveness of human aggressive facial displays, but are rated as ambivalent or unattractive by females . Until very recently, studies of human iris coloration focused primarily on European populations, where the greatest range and variety of eye colours—from dark brown to pale blue—are found.
Iris colour phenotypes are determined by amounts of melanin and by the ratio of eumelanin to phaeomelanin in the iris, with brown eyes having a higher ratio than light eyes [ 8889 ]. Other categorical eye colours, such as blue, green and hazel, are common in Europe and parts of the Middle East, and Central and South Asia, with Europeans having the lightest eye colours [ 88 ].
The sets of genetic markers associated with variation in iris coloration in Europe, South Asia and East Asia are distinct, and relatively little is known of the combination of evolutionary forces—including natural and sexual selection—that influenced their distribution [ 89 ].
Dark iris coloration is associated with less scattering of intraocular light, a trait that may be protective under conditions of bright sunlight and high UVR.
Blue eye coloration, on the other hand, is associated with greater intraocular light scattering and a higher level of melatonin suppression, traits that may have been adaptive under highly seasonal sunshine regimes in northwestern Eurasia [ ]. Blue-eyed women have been found to be preferred by blue-eyed men, possibly as a manifestation of a male adaptation for the detection of extra-pair paternity based on eye colour, as a phenotypically based assurance of paternity [ ].
Arguments for the action of natural and sexual selection on iris colour need to be examined with great care as more data on the genetic basis of the trait are revealed. A recent study showing that the genetic markers associated with iris coloration are also associated with skin and hair pigmentation traits suggests that iris coloration was a pleitropic effect associated with selection on pigmentation genes whose primary effect was skin or hair pigmentation, not iris coloration [ 89 ].
The genetic basis of human coloration is complex because some genetic variants affect all pigmentary systems—skin, hair and eyes—through pleiotropic effects, while others affect only one type [ ] and because different genes and gene combinations can create similar coloration phenotypes. Despite the technical difficulties of such studies, the fascination of humans with their own coloration phenotypes will certainly continue to propel research forward quickly.
Skin, hair and eye coloration in humans is variable, and has been influenced by different combinations of evolutionary forces. Skin coloration has been strongly influenced by natural selection, globally and throughout human prehistory, because of the importance of melanin as a natural sunscreen on naked skin. The role of natural selection in the evolution of hair and eye coloration appears to have been negligible, but genetic bottlenecks followed by sexual selection may have played more significant roles in establishing the patterns of variation recognized outside of Africa.
In recent centuries, humans have migrated faster and over longer distances than during any time in prehistory. Many of these movements have brought people into regions with markedly different solar regimes than their homelands. Many people now live under levels of solar radiation that are much stronger, or much weaker and more seasonal, than those under which their ancestors evolved. These rapid changes in living circumstances have created significant health problems resulting from too much UVR exposure skin cancer, accelerated ageing of the skin and from too little UVR exposure vitamin D deficiency and its many sequelae that have greatly impacted individual well-being and public health.
Mitigating these problems is now the focus of considerable attention in many health professions [ — ]. Rapid, long-distance migrations have also brought people together from disparate and widely separated places, creating unprecedented and novel opportunities for gene flow.
The twenty-first century world contains a sepia rainbow of human skin colours, created from old and new combinations of skin colour—related genetic markers.
The effects of these new genetic admixtures on health are not known. More significant to health and overall human well-being, however, are the problems of social segregation and behavioural bias that are rooted in cultural constructions of skin colour—based race categories [ 87 ]. Humans are visually oriented primates, and our varied colours are badges of our recently shared evolutionary history. Our skin colours unite us, not divide us. Tim and two anonymous reviewers provided excellent suggestions for improvement of this contribution.
We thank Theresa Wilson of Penn State for providing comprehensive support and assistance to our research programme, including the maintenance of our reference library and preparation of this manuscript. The authors contributed equally to the conception and design of this paper and to the drafting and revising of the article for important intellectual content; they also gave the final approval of the version to be published.
National Center for Biotechnology InformationU. Published online May Nina G. Jablonski and George Chaplin. Author information Article notes Copyright and License information Disclaimer. Accepted Dec 9. This article has been cited by other articles in PMC.
Abstract Humans are a colourful species of primate, with human skin, hair and eye coloration having been influenced by a great variety of evolutionary forces throughout prehistory. Keywords: eumelanin, phaeomelanin, ultraviolet radiation, natural selection, sexual selection, genetic drift. Introduction Discussions of the cardinal features of the human lineage usually focus on bipedalism, relative brain size, language and technology, and ignore the remarkable distinctions of the integument and eyes that have figured importantly in human evolution.
Human coloration in context Like most mammals, primates have hair covering most of their bodies. Variation in human skin coloration is mostly a product of natural selection Skin colour as measured by skin reflectance and levels of UVR are highly correlated. Hair and eye coloration are not under strong natural selection Like skin, the coloration of human hair and eyes is determined primarily by the amount and type of melanin produced and stored in melanosomes [ 8889 ].
Conclusion Skin, hair and eye coloration in humans is variable, and has been influenced by different combinations of evolutionary forces.
Authors' contributions The authors contributed equally to the conception and design of this paper and to the drafting and revising of the article for important intellectual content; they also gave the final approval of the version to be published.
Competing interests We have no competing interests. Funding We received no funding for this study. References 1. Caro T. The colours of extant mammals.
Cell Dev. Walsberg GE. Consequences of skin color and fur properties for solar heat gain and ultraviolet irradiance in two mammals. B— The adaptive significance of coloration in mammals. BioScience 55— Body temperature, thermoregulatory behaviour and pelt characteristics of three colour morphs of springbok Antidorcas marsupialis. A— Chaplin G, Jablonski NG. The integument of the odd-nosed colobines. In The natural history of the Doucs and snub-nosed monkeys ed.
Jablonski NG, editor. Singapore: World Scientific Publishing Co. The primate palette: the evolution of primate coloration. Contrasting coloration in terrestrial mammals. Kingdon JS. The role of visual signals and face patterns in African forest monkeys guenons of the genus Cercopithecus. Structural colouration of mammalian skin: convergent evolution of coherently scattering dermal collagen arrays. Sexual swellings advertise female quality in wild baboons. Nature— Nunn CL.
The evolution of exaggerated sexual swellings in primates and the graded-signal hypothesis. Familiarity affects the assessment of female facial signals of fertility by free-ranging male rhesus macaques. Social correlates of testosterone and ornamentation in male mandrills. Setchell JM. Color in competition contexts in non-human animals. Mundy N, Kelly J. Investigation of the role of the agouti signaling protein gene ASIP in coat color evolution in primates.
Genome 17— Held LI. The evo-devo puzzle of human hair patterning. Jablonski NG. The evolution of human skin and skin color. L'application est très simple, la texture est très agréable et la tenue est irréprochable.
No pigment around eyes
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